Well, Bering is already a slow system compared to Hudson so no need to do something here, GRN could destroy the lane in Magellan or even better in Cortez during their push there, Kepler - Galileo part is also quite easy INRP, dark matter fields drifted a bit and destroyed/damaged lanes/forced Ames to relocate to one side or another. Nice Idea overall, partially already implemented.
Actually, Kepler is a pretty small system as it stands, anyway. It wouldn't be so bad to have to cruise the length of it, though if the dark matter clouds crept between the gates, that would force large transports around them, since they're accompanied by dense asteroid fields. It would be an interesting contrast to Bering, which only has a single gate connection into the system. I can see Ames either being towed to another part of Kepler, or even sticking things out where its currently placed, depending on how the clouds move.
Perhaps the fields could elongate and swirl around the central part of the system, though I doubt a station has enough of a gravity well to affect nebulae like that, unless Ames unveils an experimental artificial gravity simulator or something. Either way, a lane-less Kepler could open Ames up towards a haven for "black science" - procedures, experiments and engineering that might not be performed in more lawful facilities, although that would be up to the Zoners that inhabit Ames, who already outsource some of the cheapest counterfeit software in Sirius.
Activity is streamlined to either of the parallel systems anyways: Magellan is in the hands of GRN, Bering is in the hands of pirates and Galileo is both slower and less developed/safe than Kepler. Merging wouldn't achieve anything new, it would just take away content without any gain in return.