I decided to start a SP campaign, since it's been years since I've done it, and I can't remember how it goes.
However, right in the beginning of the freeport cutscene, as soon as the Nomads arrive, I lost sound. Now I'm watching Trent on Manhattan with no sounds...
If I press F1, I hear menu sounds and everything, I looked in the menu, and I have all the sounds turned up, as well as my system sounds.