There is one I used to do on my Zoner whale...It is not too long also the profit is not exactly the best, but Zoner whales can't be too picky....
So the route is: Buy robotics at Aland shipyard in O3, take them to Freeport 10 in Tau 37, buy Niobium on the Freeport and take it back to Aland...I think you make like 20-30 mill on a full run...
Pineal Amulets to somewhere near O-74 (Delta, maybe?), alien organisms to Bering, passengers to Gran Canaria (dunno how appropriate this is in a whale...I do (did?) it in a liner), vodka to Tau-37, then either food towards Theta, or head back to Baffin for more amulets.
With a little creative thinking and Freelancer Companion or the like, you can easily find a route from freeport to freeport all across Sirius, never having to visit those pesky houses with their pesky rules and restrictions.
Plus, make sure your liquor cabinet is always fully stocked, and you never have to worry about the more violent elements of the population. Just be wary of glowing things.
Buy Premium Scrap at Brunswick Shrine in Baffin, sell it at Valetta Shipyard (Omicron Alpha) or Singapore Shipyard (Tau 44). Buy Niobium Ore from Fort SIloso, take it to Brunswick Shrine in Baffin. Repeat.
If Fort SIloso runs out of Niobium Ore, poke an IMG to mine some for you.
If Brunswick Shrine runs out of Premium Scrap or gets its Niobium Ore stock limit reached, take some Niobium Ore on a Zoner 3.6ker to Planet Denver and go fetch some Pscrap to any Texas or Puerto Rico base that sells it (La Fortaleza, Tinker's Haven, Beaumont Spire, etc), and Bring it to Brunswick Shrine in Baffin so you can grab it later with your Whale.