Some people might object to this but, I often check the player list for pirate locations. In case you know which pirate groups are active in your routes you can plan your trips around them. Or if you're looking for interaction you can plan your trips through areas they may be waiting in.
I'd also like to say that if you find yourself running a certain payload often, find out what faction would likely do the same thing and get tagged and ID'd to match it. That way you can RP as an employee of that organization, and make things just that much more interesting.