Combat testing indicates that the Nomads will be just as pesky to fight against as the [REDACTED] and [REDACTED] in vanilla: They have a higher range and due to how Starsector handles combat, they will always try to keep the best possible distance. They will also surround the player very quickly, which is bad news to anything with small shield arcs.
Ideally, you can counter the Nomads with carriers, tanky battleships (like in this video the Temeraire) or ships with the teleporter ability (Tokugawa, Aquilon). Missile spam works very well, too (Overlord, Willow Grove LABC).
The Ishtar is an absolute pain in the ass and you will likely never see more than one or two on the battlefield. In this scripted mission, the AI decided to hold all three of them back as reinforcements, and the moment they appear, things go downhill very quickly.