What starting reputations will be better for 4.78? Don't even ask to make everyone neutral or friendly. This will not be the case for Discovery. You'll still start hostile/neutral to pirates and will have to struggle to make friends with them. And there will be extremely hostile factions in each house (Xenos in Liberty, Unioners in Rheinland, GC in Kusari and Mollys in Bretonia) that will be most difficult to befriend with.
So, what about other pirates? What other pirate factions should be hostile, what should be neutral?