Trade through high pirate activity areas or smuggler through highly policed areas or both. Great fun!
One particular group have to both dodge pirates of almost every unlawful faction on the server AND the law enforcers their entire run on both the outward and return run.
It tends to keep you on your toes plus, a bit of RP never hurts anyone. You soon get to know the best RPers on that route and who you do and who you don't want to meet. After a while, they get to know you too and actually look out for you....
Plus, put a couple of variant runs in, just to keep your hand in.