Well, I really don't care about any hostile NPCs, and I'm unaware of any IDs that will allow me to complete this trade route while being immune from pirating by players with Molly, Gaian, Corsair, Liberty Rogue, Lane Hacker, Xeno, Outcast, or independent pirate IDs.
Take Terrofarming Gases from Dortmund station in New Berlin to Isehara Terraforming Outpost in Okinawa. From there, pick up Plutonium and bring it to Dortmund. ~6 Million profit per run in a Behemoth. Super fast and almost zero pirate activity. Though I think Plutonium is restricted by Kusari, so don't get caught:P