I'd be in favor of removing or merging some systems.
Omicron-100 seems kind of useless now that there is Mu. Maybe put the necessary ship sale locations or bases of o100 into Mu and remove o100?
This maybe doesnt go into the system map issue, but I'd restore omicron Minor to its 4.85 size (add some of the wrecks and the busted planet if you want). Trying to find jumpholes or players in the huge version was always terribly annoying. Also remove the minefield in Mu, its also terribly annoying, and minefields of that size in that location also seemed very unrealistic because of the effort involved into creating it.
I'd also merge omicron 81 and 86 (maybe I confused the names, I mean the 2 Systems west of Alpha), and make flying through it to get from Alpha to Tau37 not take too long (so the 2 jhs close together). Separating systems like that turns activity hubs into empty wastelands.
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