As a long time player, the most annoying thing to me is the long travel times between activity pockets. Unless you have chars spread all over the place, it can take a lot of time, and usually the travel ends up not even being worth it, with the activity moving off to somewhere else, people logging off, F1 to another location, or feel like not talking.
Also, it's always a problem with disco that at least half of the population online at the time is not much interested in any interaction and they usually just fly off to do their random business, everyone in another system. With less and less people around, finding anyone to do anything with is quite a chore at times. Especially if you're not into getting a tag on and sucking the same few people's imaginary parts in a closed off circlejerk environment day in and day out.