For major Outcast-to-the-bone pilots, withdrawrals include death, first weakness, dizzyness , cramps and headaches, then it gets worse untill the user dies.
as for a breath of cardi, i's say some slight dizzyniess, slight weakness, headaches and a bit of nausea
as for dependancy, i think it would be hard to become completely addicted and dependant in one dose, about 2 weeks of heavy useage will get you mortaly dependant