If you trade on dangerous routes, then you have to pay close attention to your sorrounding field. So you can turn around the ship in the right time so before they get in range to fire their Disruptors. Trading in threatening zones is hardcore - if you don't have the time to change sometimes the course just to evade enemies you better search for another route. Just my opinion.
I do not trading in Nomad territory either. Would be stupid.;)